
All there is in the Dead Space universe is death and the cold vastness that surrounds you. It is not too far of a stretch to imagine women protectively clutching their babies as they set upon by necromorphs only to turn and rip their child apart.

She eventually succumbs to her injuries the same time the baby's cries stop. It looked like she was crawling to the crying baby which was probably hers. You go further and you hear a woman crying, crawling on the ground towards a gate that separates you from her. You hear from inside one of them the cries of a baby unattended, endlessly wailing as all the sound of chaos and death goes away.
In Titan Heights, you can hear and see hundreds of civilians in apartment complex who somehow failed to escape.In one section of the hospital ward, as Isaac gets up after dealing with the Slasher that pinned him down, you can hear a faint sigh and a flatline suddenly going off at one of the nearby beds the man's last breath.

It's also implied throughout the game that Nicole was one of the only things in his life that actually made him happy.
